Amtas is used alone or together with other medicines to lower hypertension (high blood pressure) in adults and children. High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. Lowering blood pressure can reduce the risk of strokes and heart attacks.

Amtas is also used to relieve chronic stable angina (chest pain) in adults.

Amtas is a calcium channel blocker. It affects the movement of calcium into the cells of the heart and blood vessels. This relaxes the blood vessels and lowers blood pressure. A lower blood pressure will increase the supply of blood and oxygen to the heart.

This medicine is available only with your doctor's prescription.

This product is available in the following dosage forms:

• Suspension
• Tablet

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Here we present VirusDetect, a bioinformatics pipeline that can efficiently analyze large-scale small RNA (sRNA) datasets for both known and novel virus identification. Administration of a standardised dose of the same colostrum pool to each calf resulted in a consistent response within the groups, allowing detailed interpretation of the cellular changes not previously described.

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The effects of this bias are demonstrated in the context of both sequence-based and non-sequence based features used for predicting protein-protein interactions. HMGB1 expression and secretion are increased via TWEAK-Fn14 interaction in atherosclerotic plaques and cultured monocytes. Indinavir sulfate is an inhibitor of the human immunodeficiency virus (HIV) protease.

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Asymmetric graves ophthalmopathy as a sole manifestation of autoimmune hypothyroidism. Moreover, after additional overexpression of ketoacid decarboxylase Aro10 and alcohol dehydrogenase Adh2, the cells were able to ferment D-xylose directly to isobutanol. The stereochemistry of the nicotinamide adenine dinucleotide-specific isocitric dehydrogenase reaction.

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Transcripts of rice seedlings treated with four C:N availabilities (1:1, 1:60, 60:1 and 60:60) were compared and two groups of genes were classified: high C:low N responsive genes and low C:high N responsive genes. Different specificities of competition were observed for different tumor cells. The basic protein transition during its spermatogenesis is studied by transmission electron microscopy of ammoniacal silver reaction and immunoelectron microscopical distribution of acetylated histone H4.

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Disruption of intestinal homeostasis can lead to inflammatory bowel diseases endowed susceptibility genes and environmental factors affecting intestinal accumulation and activation of colitogenic phagocytes. Clinical data and blood samples of 257 individuals (including 75 affected individuals) from 26 different kindreds were collected. With implementation of the appropriate quality tools, programs can learn to formulate their plans, implement them, measure the results, improve outcomes, and sustain themselves.

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Because head and neck squamous cell carcinomas (HNSCC) are characterized by a distinct intertumorigenic and intratumorigenic heterogeneity, they often show substantial differences in the response to established therapy strategies. These findings indicate that miR-503 suppresses glioma cell growth by negatively regulating the expression of L1CAM. Moreover, we explain the formation of these chains using a simple model.

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Effect of acute paraquat poisoning on CYP450 isoforms activity in rats by cocktail method. Immigration and poverty in Africa has led to midwives providing nursing care to immigrant mothers in a culturally sensitive environment. Parkinson disease is a complex, multifactorial neurodegenerative disease.

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Effects on alpha-mannosidase on the active site of Japanese encephalitis viral receptor. Nine young (18-25 years) and 10 middle-aged (45-65 years) sedentary women, and 10 young and 10 middle-aged trained women participated in a meal/physical activity trial. There are many orphan G protein-coupled receptors (GPCRs) for which ligands have not yet been identified. The number of bridges and the introduction of the sulfur atom have been investigated to provide disparate synthetic routes. Different groups including ours have shown that curcumin induces melanoma cell apoptosis, here we focused the role of mammalian Sterile 20-like kinase 1 (MST1) in it.

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A successful pancreas transplantation is often able to slow the progression, stabilize, and even reverse many microvascular and macrovascular complications of diabetes. Herein, we postulate that safranal, an active constituent of Crocus sativus, owing to its strong antioxidant and anti-apoptotic potential, could be a valuable molecule in alleviating myocardial ischemia-reperfusion (IR) injury. Glomerular disease: association of FSGS histologic variants with patient outcomes. Here we present our experience and the results obtained by adopting surgical treatment. In such circumstances the transvitreal approach is of an evident benefit since it also allows removing the intraocular hemorrhage which is a potential source of severe vitreoretinal proliferation.

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Effectual way of spontaneous fabrication of scalable, ordered fractal-like structures by controlling Saffman-Taylor instability in a lifted Hele-Shaw cell is deployed here. Direction and speed tuning of motor-cortex multi-unit activity and local field potentials during reaching movements. The experimental VCD spectra and corresponding population-weighted theoretical VCD spectra were found to be in excellent agreement in CCl(4) solution in the 1800-850 cm(-1) region, which allowed unambiguous determination of the absolute configurations of (-)-1 and (-)-2 as 7S,10S and 7S,10S, respectively. Hepatitis B surface antigen (HBsAg), as a model sample, was employed to evaluate the characteristics of the biosensor.

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5-Bromo-3-(4-fluoro-phenyl-sulfon-yl)-2,7-dimethyl-1-benzofuran. Based on the distended intestinal sac method, we isolated crypt epithelial cells from the mid-jejunum on Days 0, 1, 3, 5, and 7 post-weaning. Chromium (Cr) being multifarious industrial used element, is considered a potential environmental threat. The rapid detection and separation of Staphylococcus aureus and group G Streptococcus was based on the affinity chromatography interactions between Fc fragment of human IgG and protein A/G (located on the cell wall of S.

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We conducted a cohort study of 20,794 white women and 18,916 black women who received care at 12 hospitals in the United States. Malignant trophoblastic tumors: immunohistochemical and flow cytometric comparison of choriocarcinoma and placental site trophoblastic tumors. Mitochondrial dysfunction induces SESN2 gene expression through Activating Transcription Factor 4. Police data are often limited, but there are no alternative gold standards.

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This contribution describes a measurement targeted at evaluating this method in order to analyze the requirements of technical aids. We have identified that SHOX2 expression or methylation are potent independent prognostic indicators for predicting LGG patient survival, and have potential to identify an important subset of LGG patients with IDHwt status with significantly better overall survival. The same result was also seen in a subgroup comparative analysis of groups of young and old adults.

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To investigate the pharmacokinetics and the pharmacodynamic effects in dorsal hand veins of the neurokinin-1 receptor antagonist SLV317. Similar mechanisms might be operating in states of widespread alterations of visceral sensitivity. Dnmt1, a major DNA methyltransferase gene, is highly expressed in many cancers and lowly expressed in normal adult cells, therefore, its overexpression is closely related to tumorigenesis. Health insurance coverage and the means by which it is paid have been topics of intense interest in recent years, but in the United States, creation of a uniform system for provision of medical care has been debated for nearly a century.

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A versatile and stable quinolin-2-one intermediate was identified, which could be reduced to the corresponding THQ with borane reagents, or to the DHQ with diisobutylaluminium hydride via a novel elimination that is more favourable at higher temperatures. After separation from the mother membrane, EVs become mobile and may travel from the extracellular space to blood and other body fluids. Our results suggest that this increase in motility may occur by decreasing gap junction and hemichannel activity and altering gene expression in the adhesion and ECM pathway. The members again screened 74 children with dental fluorosis in the field to categorize in to different grades of fluorosis for assessment of inter-examiner reliability. The symmetric components of the oscillations have consistent mutual phase relations for normal subjects, so that the amplitudes alone can be used as sufficient parameters to characterize the body center of mass oscillations.

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Department of Medical Education, Army Medical College, NUST, Rawalpindi, Pakistan, during February and March 2012. These results are in line with the hypothesis that a subgroup of early RA patients exhibits pain that is not inflammatory mediated, where alternative treatment strategies to traditional antiinflammatory medications need to be considered. Routine Surveillance Versus Independent Assessment by an Outcome Adjudication Committee in Assessing Patients for Sternal Surgical Site Infections After Cardiac Surgery.

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Microarray analyses revealed that many genes encoding metabolic enzymes, including those involved in cell wall metabolism and lignin biosynthesis, were downregulated throughout anther development in rpk2 mutants. We present herein a series of 11 patients treated with the OTSS technique for a variety of indications.

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Anorexia Nervosa (AN) is a debilitating, sometimes fatal eating disorder (ED) whereby restraint of appetite and emotion is concomitant with an inflexible, attention-to-detail perfectionist cognitive style and obsessive-compulsive behaviour. The aim of this in vitro study was to evaluate and compare the microleakage of restorations using low shrinkage silorane-based dental composite and methacrylate-based dental composites in Class II cavity at the occlusal and gingival margins.

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For gray-scale ultrasonography, each thyroid gland of all individuals graded with gray-scale grading (GSG), which was determined according to the gland size, parenchymal structure, echogenicity, micronodulation, contour irregularity, and existence of hyperechoic septa. Mixed medullary-follicular carcinoma of the thyroid: diagnostic dilemmas in fine-needle aspiration cytology. We found an increased mortality of our BP patients compared with the general population. The mechanism of action of BUdR was revealed by the observation that exogenous IL-4 alone induced both mu- and TCR transcripts in the transformed cells. After two months the patient had a bagatelle trauma at home, which caused an exacerbation of the back pain.

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Pneumococcal Vaccination in Low-Income Latinos: An Unexpected Trend in Oregon Community Health Centers. More recently, soluble uric acid has been reported to stimulate proliferation of vascular smooth muscle cells, inhibit endothelial function, cause renal vasoconstriction, impair renal blood flow autoregulation, and induce inflammatory response via crystal-independent mechanisms. We illustrate how one can investigate whether individuals are similar with respect to their intraindividual structure of variation, and whether this structure is similar to the structure of interindividual variation. These studies investigating the gene-environmental relationship will contribute to the development of tailor-made medicine in the future.

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Flow cytometric quantification of intraperitoneal free tumor cells in patients with peritoneal metastasis. Twenty-eight domestic pigs, 6 to 8 weeks old, underwent osteotomy of the right mandible and placement of a distractor appliance. In reproductive age women, detection of CRP for cardiovascular risk assessment during menstruation might not be appropriate. Herpes zoster, unlike chickenpox, is not associated with increased fetal risk.

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An ensemble of biological shapes can be represented and analyzed with a dense set of point correspondences. The modified tension-band technique is widely accepted for internal fixation. However, biologists working in these two areas are seeing their fields converge.

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Global climate change may have large impacts on water supplies, drought or flood frequencies and magnitudes in local and regional hydrologic systems. The unit ends with a brief description of the limitations of microarrays and discusses how microarrays are being rapidly replaced by DNA sequencing technologies.

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The anaphase-telophase Allium test showed no effect for the glyphosate isopropylamine salt, but a significant increase in chromosome aberrations appeared after treatment with Roundup at concentrations of 1.44 and 2.88 mg/l when calculated as glyphosate isopropylamine. As a result, there has been a recent push towards pragmatic trials that better mimic real-world conditions.

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The incremental cost-effectiveness ratio (icer) of zoledronic acid compared with clodronate was calculated as the ratio of the difference in cost to the difference in quality-adjusted life years (qalys). Infected femoral shaft fractures and femoral nonunions are difficult to manage. Effective integration of systems biology, biomarkers, biosimulation and modelling in streamlining drug development. We probed the susceptibility of the cysteine substitution mutants to covalent modification by charged, sulfhydryl reagents added extracellularly.

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After being subjected to static compressive force with or without caffeine administration, the conditioned media from the PDLtm were used for the OB/pre-OC co-cultures to induce osteoclastogenesis. Here, we focus on bacterial regulatory mechanisms that are mediated by RNA helicases belonging to superfamily 2, which includes DEAD-box and DEAH-box helicases. We thoroughly analysed internal genitalia at surgery and by histological examination. The positive trends are only significant over continuous permafrost, with non-significant or negative EF and precipitation trends over isolated, sporadic, and discontinuous permafrost areas. A reduction of the steroid doses needed is particularly important.

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We investigate the degree of control that can be exercised over an optically trapped microscopic non-spherical force probe. Furthermore, binding of phosphorylated p27/Cdk2/E to the E3 complex showed positive cooperativity.

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In addition to mediating several physiological functions, nitric oxide (NO) has been implicated in the cytotoxicities observed following activation of macrophages or excess stimulation of neurons by glutamate. Inherited prostate cancer susceptibility genes discovered thus far encode participants in host responses to infection. 1962.-This report deals with a comparison of the acid-soluble nucleotides from a group A, type 12, beta-hemolytic streptococcus and a derived stable L form. MiR-221/-222 differentiate prognostic groups in advanced breast cancers and influence cell invasion.

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By subsequently sorting trials based on whether the distractor was strongly represented or suppressed by the visual system - as evident in the accuracy (Exp. Polyclonal antibodies were generated in guinea pig and rabbit and showed that collagen XXIII has a transmembranous form and a shed form. Multiple parameters were evaluated for the development of colorectal cancer or colorectal polyps.

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Nuclei of the human breast epithelial cells, MCF-10A, transfected with the c-Ha-ras oncogene, the ras proto-oncogene and the plasmid Homer 6 only, were studied by image analysis after Feulgen staining. However, the role of PCAT-1 on non-small cell lung cancer (NSCLC) remains unclear.

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Fabrication and characterization of graphene-based hybrid nanocomposite: assessment of antibacterial potential and biomedical application. An eco-friendly, facile and scalable hydrothermal approach, in which the reduction and functionalization of graphite oxide (GO) are completed in one pot, is proposed for the synthesis of monolayer 3-aminopropyltriethoxysilane (APTES)-functionalized graphenes (A-FGs). Erlotinib, cabozantinib, or erlotinib plus cabozantinib as second-line or third-line treatment of patients with EGFR wild-type advanced non-small-cell lung cancer (ECOG-ACRIN 1512): a randomised, controlled, open-label, multicentre, phase 2 trial.

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Here, using a technique to isolate and culture adventitial fibroblasts (AdvFBs) and vasa vasorum endothelial cells (VVECs) from the adventitia of pulmonary arteries, we report that hypoxia-activated pulmonary artery AdvFBs exhibited pro-angiogenic properties and influenced the angiogenic phenotype of VVEC, in a process of cell-cell communication involving endothelin-1 (ET-1). This approach may be particularly useful in the study of organisms within specific disease-associated environments such as the periodontal pocket. Cold agglutinin haemolytic anaemia in this instance suggests the possibility of an autoimmune aetiology. Characterization and source apportionment of size-segregated atmospheric particulate matter collected at ground level and from the urban canopy in Tianjin. ET receptor antagonists also impressively improved systemic and pulmonary hemodynamics in patients with CHF, without causing neurohormonal activation.

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The strain amplification capability of interface structures in the order of 10 predicted by the models suggests a new explanation for the levels of strain required in bone homoeostasis for maintenance and adaptation. We aimed to assess knowledge of HIV in relation to sexual risk behaviors among adolescents seeking care in our pediatric emergency department and to assess sources of HIV knowledge among this population. We present a rare case of neurosarcoidosis manifesting as acute hydrocephalus with dilatation of all ventricles, particularly the fourth. Undetected OSAHS could help explain the increased risk associated with depression. Drivers that may influence the incidence of emerging infectious animal diseases in both the short (next 5 years) and medium term (10-15 years) were identified.

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Repair of Vascular Ring With Right-Sided Interrupted Aortic Arch and Right-Sided Descending Aorta. Interindividual variability of antioxidant enzyme activity in healthy young adults was partially explained by significant associations with three known genetic polymorphisms, and was further modified by gender and ethnicity. To our knowledge, this is the first report of polyols and trehalose in fungal propagules produced over a range of temperature or pH. The untreated and treated zeolite was characterized by XPS and XRD techniques. This mutant showed decreased production of several exoproteins such as alpha- and beta-hemolysins, DNase, coagulase and extracellular protein A.

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Association between slow-wave activity, cognition and behaviour in children with sleep-disordered breathing. One of the main factors limiting the thickness of a tissue construct and its consequential viability and applicability in vivo, is the control of oxygen supply to the cell microenvironment, as passive diffusion is limited to a very thin layer.

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Therefore, miRNAs hold great potential as clinical biomarkers of physiological and pathological states and extensive efforts are underway to develop efficient approaches for their detection. While the nuclear localisation signal of free p50 is extremely susceptible to cleavage with trypsin the same site is masked in the presence of the C-terminal ankyrin repeats of p105 and, to a lesser extent MAD-3.

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Effect of UV irradiation on the physico-chemical properties of iron crosslinked collagen. Immunohistochemistry showed an extensive positive staining to androgen receptor. Dermaseptins from Phyllomedusa oreades and Phyllomedusa distincta: liposomes fusion and/or lysis investigated by fluorescence and atomic force microscopy. Previous research has identified a number of factors that appear to moderate the behavioural response to glucose administration.

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Randomized clinical trials are needed to evaluate the efficacy and clinical utility of the FIRM ablation approach for treating AF. Disturbances of the thyroid hormone concentration are often connected with thyroid gland enlargement.