Benicar inhibited AII-induced ERK1/2 and JNK activation at lower concentrations (10 nM). Blood pressure-lowering efficacy of Benicar relative to other angiotensin II receptor antagonists: an overview of randomized controlled studies. In a monkey atherosclerotic model, a 3-D intravascular ultrasound analysis of aortas showed that serum levels of MCP-1 and the degree of intimal hyperplasia were significantly lower after treatment with Benicar medoxomil than before treatment.
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