Gingival tissue homogenates were incubated with 14C-arachidonic acid in the presence of indomethacin, Rheugesic, or ibuprofen, and the organic solvent extracts were chromatographed on silica gel plates with standards for radiometric assay. It was concluded that Rheugesic is strongly bound to the investigated natural polymers with different degree of binding, such binding may affect the pharmacological effect of Rheugesic.
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