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Spironolacton (Spironolactone)
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Spironolactone

Spironolacton is currently being used in dermatology as an antiandrogen or anti-male hormone therapy for the treatment of acne, diffuse hair loss in females, and hirsutism. This drug has a minor estrogen effect on the scalp, hair, skin and body. Acne improves within 2 to 4 months and skin oiliness decreases. The dose of Spironolacton for acne in females is 50 - 150mg a day for at least 1 to 2 years with periodic rest periods, to determine if the drug is still needed. Hirsutism or increased facial and body hair is treated with doses of 100 - 200mg a day for 2 years with minimal rest periods. The first change in the body hair is decreased growth rate, then finer hair and ultimately decreased hair.

Other names for this medication:
Spironolactone, Aldactone, Aldactazide, Aldactazine, Aldazida, Aldazide, Aldozone, Alexan, Alizar, Carpiaton, Espirone, Espironolactona, Expal, Kespirona, Lanx, Letonal, Osiren, Osyrol, Practon, Prilactone, Spiractin, Spiresis, Spirix, Spiroctan, Spirolang, Spirolon, Spiron, Spirono, Spironolacton, Spironolactona, Spironolakton, Spironolattone, Spirotone, Verospiron, Xenalon,

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Spironolacton comes as a tablet and suspension (liquid; Carospir) to take by mouth. It usually is taken once or twice a day. Take Spironolacton suspension consistently either with food or without food each time. Take Spironolacton at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Spironolacton exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Shake the oral suspension well before each use to mix the medication evenly.

Your doctor may start you on a low dose of Spironolacton and gradually increase your dose.

Spironolacton tablets and suspension release the medication differently in your body and cannot be substituted for one another. Only take the Spironolacton product prescribed by your doctor and do not switch to a different Spironolacton product unless your doctor says that you should.

Spironolacton controls high blood pressure, edema, heart failure, and hyperaldosteronism but does not cure these conditions. It may take about 2 weeks or longer before the full effect of Spironolacton occurs. Continue to take Spironolacton even if you feel well. Do not stop taking Spironolacton without talking to your doctor.

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While oral administration of glucose achieved a level of hyperglycaemia and hyperinsulinaemia that markedly accelerates glycogen storage in other species, the rate of glycogen storage following oral supplementation was not different to control conditions. The tissue directly surrounding incisions in mouse hind paws undergoes large changes in the content of specific cytokines in addition to demonstrating edema and nociceptive sensitization. However, this type of incision can affect the frontal view and shape of the breast.

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The remarkable downregulation of Wnt7a mRNA in response to EE was considered to be important to understand the various uterine phenomena affected by ER agonists. Thus, we hypothesized that lncRNA expression also changes after stroke. CER1 gene variations associated with bone mineral density, bone markers, and early menopause in postmenopausal women. EXP3174, which is an active metabolite of losartan, almost completely blunted Ang II-mediated RGS2 mRNA expression without direct stimulation of RGS2 mRNA expression.

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Level of HER2 gene amplification predicts response and overall survival in HER2-positive advanced gastric cancer treated with trastuzumab. When the sucrose solution was offered as the only source of calories, rats treated with ghrelin infused in the ventricle and site-specifically increased sucrose consumption.

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While the US and Brazil are often quoted as the countries with the highest demand for plastic surgery, according to the presented analysis, other countries surpass these countries in surgical procedures per capita. During glacial terminations, changes in Patagonia apparently preceded sea-ice reduction, indicating that multiple mechanisms may be responsible for different phases of CO2 increase during glacial terminations. Compared with the original vowel sounds, the degraded sounds increased the amplitude of the right-hemispheric N1m without affecting the latency whereas the amplitude and latency of the N1m in the left hemisphere remained unaffected.

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Although the mechanism behind the contralateral changes is unclear, we suggest that the nervous system is involved in the cross-transfer effects. Poststroke depression (PSD) leads to impaired functional recovery and increased mortality, yet physiological mechanisms are unknown. This article is concerned with the important topic of infections associated with organ transplantation and includes a discussion on four subtopics. Proceedings of the University of Pennsylvania 5th annual conference on statistical issues in clinical trials: emerging statistical issues in biomarker validation for clinical trials.

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Further development of a transcervical technique for artificial insemination in sheep using previously frozen semen. pneumoniae infection has also been associated with chronic lung disease and bronchial asthma. To test this hypothesis, we used time-lapse fluorescent microscopy and tumor cylindroids to quantify the accumulation of chemotaxis machinery knockouts, including strains lacking individual cell surface chemoreceptors, chemotaxis signal transduction pathway enzymes, and the flagella and motor assemblies. Diffuse malignant pleural mesothelioma: options in surgical treatment. We highlight the basic functions of these cells, their changes in patients with various forms of IgG4-RD, and insight gained from animal models of the disease.

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Changes have to be initiated by the investigators themselves as they know all the specificities of the field. This theory was investigated in an event-related fMRI study that separated the time course of activation before and during movement to distinguish advance planning from online control. A separate posterior positive pattern then emerges that seems to repeat the topography of the P1. Direct synthesis of chiral tertiary diphosphines via Pd(II)-catalyzed asymmetric hydrophosphination of dienones.

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Activation of NLRP3 and AIM2 inflammasomes by Porphyromonas gingivalis infection. It should always be borne in mind that topical diclofenac sodium should be used with caution in patients with compromised ocular surface. Combination of upflow anaerobic sludge blanket (UASB) and membrane bioreactor (MBR) for berberine reduction from wastewater and the effects of berberine on bacterial community dynamics.

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The aim of this study is to clarify the effect of modafinil on the ventilatory control. From the top ten diseases, it is considered that the prevention of animal-to-human transmission should be emphasized.

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DNA vaccines combine remarkable genetic and chemical stability with proven safety and efficacy in animal models, while remaining less immunogenic in humans. Mouse podocytes were treated with Aldo in the presence or absence of 3-methyladenine and N-acetylcysteine. In a mouse model of lung transplantation, concurrent viral infection and allogeneic transplantation increased epithelial injury and this was followed by exaggerated accumulation of macrophages and collagen deposition.

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Protective effect of thiopreperazine and of tranxenemic acid (AMCHA) on gastric vasomotor response induced by polymyxin B in the rat THE RELATIVE THERMAL DEATH RATES OF YOUNG AND MATURE BACTERIAL CELLS. A close correlation with intrasplenic pressure recording and a high reproducibility in chronic conditions with this technique were confirmed in our laboratory. These activity changes are associated with synaptic scaling, manifested in vitro by an increase in mEPSC amplitude and in vivo by an increase in spine size.

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Changes in fat and carbohydrate metabolism after administration of cholinomimetic agents in anesthetized rats Knowledge about the total waste generated by the production of consumer goods can help raise awareness among policy-makers, producers and consumers of the benefits of closing loops in a future circular economy, avoiding unnecessary production and production steps and associated generation of large amounts of waste.

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Given the social context of HIV disease management, more research is needed to explicate underlying mechanisms involved in HIV care and treatment that differ by relational factors for young Black MSM living with HIV. Future investigations need to define the mechanism of activation of the decidual renin-angiotensin system and the release of placental factors in the pathogenesis of preeclampsia.

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We demonstrate in both in vitro and in vivo models of breast cancer that combination therapy with a low dose of Dox and an anti-survivin siRNA nanodrug (MN-siBIRC5) is superior to mono-therapy with either low- or high-dose Dox alone. The colorimetric estimation of stilboestrol, hexoestrol and their glucuronides in urine. Note-, phrase- and song-specific acoustic variables contributing to the individuality of male duet song in the Bornean southern gibbon (Hylobates albibarbis).

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However, successful ventilation techniques also expanded the treatment possibilities for more severely ill patients who require deeper sedation levels. Results from traditional manual microvessel density (MVD) hotspot count and computerized hotspot count were compared and the relation between hotspot MVD count and survival rate was evaluated. After the second postnatal peak, activity is increased by amino acids or cortisol and this is insensitive to actinomycin D inhibition.

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Generally, these two processes are intertwined and it is challenging to determine which proteins contribute to the sensing or amplification process, particularly in multicellular organisms. Short pulse eye-safe laser with a stimulated Raman scattering self-conversion based on a Nd:KGW crystal.

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The Relation of White-on-White Standard Automated Perimetry, Short Wavelength Perimetry, and Optic Coherence Tomography Parameters in Ocular Hypertension. Insomnia severity did not predict sleep-related safety behaviors. Their incidence was 75.5 for the year 2000 and 70.5 in year 2002 for every 1000 workers paying national insurance. Phenolic extracts from BSG, particularly the pale BSG extracts, have the ability to reduce a stimulated cytokine production and may also protect against cellular oxidative stress.

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These E1-deletion vectors were also deficient in cellular transformation, shut-off of host cell protein synthesis, and production of cytopathic effects, even at high multiplicities of infection. The effect of the three platelet-derived growth factor (PDGF) isoforms AA, AB and BB on the induction of the early growth response genes c-fos, egr-1 and c-myc mRNA in vascular smooth muscle cells from rat was compared with their respective mitogenic potency. However, T lymphocytes derived from CD28-/- mutant mice had impaired responses to lectins. To examine the usefulness of urine sodium (Na) excretion in spot or timed urine samples to estimate population dietary Na intake relative to the gold standard of 24-hour (h) urinary Na. Geographical Information System and heatmaps were used to describe the epidemiological characteristics.

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Mouse gene-targeting studies have provided convincing evidence of the indispensable and dispensable roles of individual members of the Rho GTPase family and the putative upstream and downstream mediators in stem cell-specific functions. Xylocarpins A-E were designated as polyoxyphragmalins, xylocarpin I was identified as a phragmalin orthoester, while xylocarpins F-H represented mexicanolides modified by ring oxidation and unusual 9,10-bond cleavage. In addition to these structural studies, the kinetic parameters of the hydrolysis of 4-methylumbelliferyl N-acetyl-chitotriose, ((GlcNAc)3-MeU), have been determined in order to further characterize the enzymatic properties of these mutant lysozymes. Investigation of extraction procedures and HPLC-DAD/MS for the determination of the brominated flame retardant tetrabromobisphenol A bis(2,3-dibromopropylether) in environmental samples.

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A specific form of bacteria-mediated gene therapy is transkingdom RNA interference. Multiple synchronous, ipsilateral, invasive foci of breast carcinomas are frequent and are associated with a poorer prognosis. Deficiencies in GH- or sex hormone-dependent signaling and the influence of sex hormones on GH biology may have a dramatic impact on liver physiology during somatic development and in adulthood. Several surgeons have found KTP laser to be the equivalent of, or superior to, the CO2 or pulsed dye lasers, and none have reported inferiority.

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The nature of the system used to induce immunity in vitro appears to argue against the possibility that lymphocytes capable of reacting against self-antigens could arise by mutation in cell culture. Penicillium chrysogenum utilizes phenylacetic acid as a side chain precursor in penicillin G biosynthesis. Application of machine learning to proteomics data: classification and biomarker identification in postgenomics biology.

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The aim of the present study was to find out whether a non-invasively measured atrial fibrillatory cycle length, alone or in combination with other non-invasive parameters, could predict sinus rhythm maintenance after cardioversion of AF. A possible rise in the soluble sugar content caused by the invertase may compensate for the decline in photosynthetic carbon assimilation indicated by the decrease in net photosynthesis. Myocardial perfusion SPECT/CT for 509 patients was included in the study.

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Post-therapy CTC level may help in evaluating therapeutic response in patients with AGC and predicting their prognosis. In hepatocarcinogenesis, multiple signaling transduction pathways, important for stem cell proliferation and differentiations, are deregulated. Boschnaside, 8-epi-iridodial glucoside a new iridoid glucoside was isolated from Boschniakia rossica Hult., and its absolute structure was determined by chemical correlation of boschnaloside tetraacetate with boschnaside tetraacetate. Consequent effects of the great cormorant (Phalacrocorax carbo sinensis) predation on parasite infection and body condition of common carp (Cyprinus carpio).

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This article has examined some of the uses of such products in treating venous ulcers, diabetic foot ulcers, and skin diseases leaving skin wounds. Tissue plasticity is well documented in the context of pancreatic regeneration and carcinogenesis, with recent reports implicating dedifferentiated islet cells both as endocrine progenitors and as the cell(s) of origin in pancreatic adenocarcinoma.

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Detection of silent cerebellar lesions by increasing the inertial load of the moving hand. prediction of length of stay (LOS) may be useful to optimise care plans to reduce the negative outcomes related to hospitalisation. Therefore we suppose that MALPDT could represent a valid therapeutic option in the treatment of infected chronic ulcers. Antibody response to Mycoplasma hyopneumoniae infection in vaccinated pigs with or without maternal antibodies induced by sow vaccination.

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It is not necessary to have the raw data available and the formula therefore opens up the possibility of reevaluating studies that are based on ACcoupled ECGs and compare the results of such studies with studies that are based on newer, DC-coupled ECGs. Biochemical and structural characterization of SplD protease from Staphylococcus aureus. The recommendations generated from the forum seek to inform ACR leadership on the best strategies to pursue to ensure the continued success of the profession in the coming decade. What Do We Mean by Poor-Grade Aneurysmal Subarachnoid Hemorrhage and What Can We Do? Limiting the inquiry to a homogenous group, those with lower extremity vascular injuries (LEVIs), may clarify these disparities.

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A prospective and comparative analysis of tissue injury after mini-open lumbar fusion and conventional technique. The risk-estimate of caregivers, but not car accidents or revocation of the driving license determines if dementia patients cease driving. These findings suggest that these phenotypes might be regulated by multiple genes, which could be detected in quantitative trait loci.

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Presuming World Health Organization predictions hold, patient demand may overwhelm medical facilities making pandemic influenza preparation and coordination essential. Further investigation is needed to gain more insight into the association between comorbidity and AD in younger people. Factor V mutations in Iranian patients with activated protein C resistance and venous thrombosis. Results showed that recent (past hour) alcohol use was significantly associated with increases in the following: (a) tonic (non-cue-elicited) cigarette craving, (b) stress cue-elicited cigarette craving, and (c) stress cue-elicited stress reactivity, in the context of high-baseline stress.

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Here we examined short-term transcriptional responses of surface water picoplankton assemblages in a deep-sea water (DSW) mixing experiment. Validity and reliability of 24h blood pressure monitoring in children and adolescents using a portable, oscillometric device. This was confirmed through the genetic mapping of each mutation to different linkage groups. Cationic liposomes (CL) are one of the most widely studied non-viral vectors for gene delivery. rhGH could enhance the growth of Bel-7402 hepatic carcinoma xenografts in nude mice.

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Therefore, hemodynamics of splenic blood vessels and the role of spleen in portal hypertension were the aim of our study. Increased hepatocellular uptake of long chain fatty acids occurs by different mechanisms in fatty livers due to obesity or excess ethanol use, contributing to development of steatohepatitis in both settings. This scheme allows for an exact adjustment of the transmission characteristic to avoid the formation of bunched noiselike pulses while the self-starting characteristic is preserved.

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Thyroid hormone deficiency alters expression of acid-base transporters in rat kidney. Atherosclerosis III: Recent Advances in Atherosclerosis Research.

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The nature of the sugar residue in the hexosemonophosphoric acid of muscle. Fractures of the distal tibial metaphysis have been only described in fracture texts without reference to a peer-reviewed study. Thus, there is a need for randomized, placebo-controlled statin studies with carefully selected groups of patients and NOD as a key end point in order to resolve queries concerning this issue. Antibodies are important in the control of blood stage Plasmodium falciparum infection. Fifth international congress of the Federation of the European societies for Trace Elements and Minerals.

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Research documentation did not include all factors that may affect group physical therapy use, and some sessions were not documented. The suitability of the arts to promote other types of health messages should be investigated further. We assessed the prevalence and distribution of cervical high-risk (hr) HPV infection and cytological abnormalities in WLWH compared with WGP in Denmark. The rates of change of retinal nerve fiber layer (RNFL) thickness, cup-to-disc (C/D) ratios, and VF mean deviation (MD) were compared between the cohorts. graminearum sensu stricto from Argentina revealed an atypical panel of strains identified through PCR genotyping as 15ADON genotypes, but producing high levels of 3ADON.

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All patients were reviewed by two pathologists, then the mixed type and cases showing other organized malignant tumors were excluded from this study. Before EEG alterations by pyridoxine-IV can be ascribed to PD/PR, these non-specific responses should be excluded first. Despite this progress, however, outcomes of hepatectomy in cirrhotic patients with portal hypertension are still uncertain. Targeting luteinizing hormone-releasing hormone: A potential therapeutics to treat gynecological and other cancers.

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A positive correlation was observed between phenotypic and genotypic diversity. The observed oral hygiene status among the 15-year-olds necessitates implementing pre-ventive as well as restorative measures to improve the oral health status of the young population.

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This study attempts to compare two possibilities of enhancing the colour of egg yolk. Waist circumference, latency to sleep, smoking, and perceived stress were independently associated with increased concentrations of CRP. Mater protein expression level in mature oocytes from 7 young (5-8 weeks old) to 7 old mice (41-68 weeks old) was compared by immunoblotting analysis. Relationship between stimulated oxidative metabolism and hydrogen peroxide formation, and intracellular killing. Although sensory and emotional evaluation of food products mostly occurs in a controlled laboratory environment, it is often criticized as it may not reflect a realistic situation for consumers.

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The Selective Monoacylglycerol Lipase Inhibitor MJN110 Produces Opioid-Sparing Effects in a Mouse Neuropathic Pain Model. Searches were conducted including any published and unpublished material, including grey literature, in the English language. Antioxidant intake and pancreatic cancer risk: the Vitamins and Lifestyle (VITAL) Study. vivax Duffy Binding Protein (PvDBP) is functionally important in the invasion process of these parasites in Duffy / DARC positive humans.

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High-field MR imaging, with its intrinsic higher signal-to-noise ratio (SNR), can enable new applications for MRI in medical alfuzosin uroxatral side effects diagnosis, or can serve to improve existing methods. Simultaneous method for analyzing dimerization and signaling of G-protein-coupled receptor in yeast by dual-color reporter system.

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A Tobacco mosaic virus (TMV)-derived vector was used to express a native Human papillomavirus type 16 (HPV-16) L1 gene in Nicotiana benthamiana by means of infectious in omeprazole generic prilosec reviews vitro RNA transcripts inoculated onto N. The aim of the study was to estimate the topographic prevalence of these lesions in gastritis related with Helicobacter pylori and to associate them with the density of bacteria. Using a quasi-experimental randomized block design, nurse anesthetists completed training under 1 of the 2 instructional design models. Online health education developers need to take extra effort to truly understand access patterns of populations being served, and whether or not access device will influence user engagement performance indicators. FAK has been shown to interact with growth factor receptors including cMET and IGF-1R.

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Despite the lack of evidence in outcome studies and limited number of high-validity otolaryngology simulators, the role of simulation continues to grow across surgical specialties Hence, it is imperative that the simulators are of high validity and construct for trainees to practice and rehearse surgical skills to develop confidence. This review discusses the in vitro abamune tablet pc and ex vivo models currently being used to study corneal penetration and evaluates their advantages and limitations with a focus on diffusion cell assemblies.

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Pyogenic granuloma (PG) is a common skin tumour whose aetiology is unknown. Decontamination of a fluvin 25 mg municipal landfill leachate from endocrine disruptors using a combined sorption/bioremoval approach.

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Real-time monitoring of the immobilization process and techniques that demonstrate that the enzymes are located inside the lortaan 100 mg a cosa serve l'equiseto pores is discussed by contrasting them to the common practice of indirectly measuring the depletion of the protein concentration or enzyme activity in the surrounding bulk phase. The brain peptidergic systems regulated by melanocortin receptors agonists, neuropeptide Y, glucagon-like peptide-1, kisspeptins and somatostatin play an important role in the etiology and pathogenesis of DM. The Behavior of the Virus of Equine Encephalomyelitis on the Chorioallantoic Membrane of the Developing Chick. Moreover, CCK is involved in the regulation of food intake and satiation.

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Unfortunately, vascular normalization is a difficult approach to apply in clinical settings. Kupffer cells play a key role in modulating the inflammatory response observed in most animal models of liver injury. Catatonic syndrome is observable in various psychiatric and physical disorders. GnRH neurons exhibited robust lumper mebendazole dose currents in response to millimolar concentrations of GABA and a picrotoxin (PTX)-sensitive, bicuculline-insensitive current that probably arises from spontaneous openings of GABAA receptors.

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