Ezetimibe and Torvast combination is used together with a proper diet to treat high cholesterol and triglyceride (fats) levels in the blood. This medicine may help prevent medical problems (eg, heart attack, stroke) caused by clogged blood vessels. It is also used to treat a condition called homozygous familial hypercholesterolemia (HoFH).

Ezetimibe is a cholesterol absorption inhibitor and Torvast is an HMG-CoA reductase inhibitor, or statin. These medicines will reduce the absorption of cholesterol from foods and the production of cholesterol in your body.

This medicine was available only with your doctor's prescription.

The Torvast/ezetimibe combination (Liptruzet(R)) was withdrawn from the United States market on June 2, 2015.

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The isolation process involves the removal of proteins, flavonoids, chlorophylls, other sterines, etc. The mean amplitudes of the EOG recordings from each eye during 12 minutes of darkness and 18 minutes of light were compared.

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An analysis using averaged EEG dynamics could discount information regarding interdependency between ongoing EEG and salient ERP features. Recording with amplifiers using continuous and alternating current in electronystagmographic practice ARA-C reduced EWS/FLI protein abundance and accordingly diminished cell viability and transformation and abrogated tumor growth in a xenograft model. Patients were categorized into normal, indeterminate and suggestive with CP based on Rosemont classification.

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The mammalian target of rapamycin (mTOR) plays a critical role in the regulation of cell growth, proliferation,and metabolism by integrating growth factor stimulation and energy/nutrient input through a complex signaling network.The mTOR kinase is a part of two structurally and functionally distinct multiple protein complexes, mTORC1 and mTORC2. On the other hand, the growth rate of the enlarged HCCs was significantly correlated with CDDP dose after normalization with creatinine clearance. The origin of NRBCs was verified and prenatal diagnosis of DMD was made at the same time. Fatty acids in liver, muscle and gonad of three tropical rays including non-methylene-interrupted dienoic fatty acids. The aim of this study was to detect prognostic factors in recurrent breast cancer metastasis.

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Eight patients were identified as having a histologically confirmed intraventricular glioblastoma. The results are discussed in terms of their clinical implications and advice to patients. To shed more light onto the function of Snu114, we have now directly analyzed snRNP and spliceosome assembly in SNU114 mutant extracts. The date palm is a dioecious perennial species of the Arecaceae for which in vitro micropropagation is essential to ensure the renewal of palm plantations. Fifty-eight frozen uterine cancer specimens were stained for FOLR1 using immunohistochemistry and results were correlated with transcript expression noted on quantitative PCR.

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The main blood vessel cell types have the capacity to activate protein kinase pathways in the presence of lipoproteins. Three case studies demonstrate the risk-based approach to accident analysis for short- and long-range transportation plans. Internalization of Ineffective Platinum Complex in Nanocapsules Renders It Cytotoxic.

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The involvement of Notch signaling in Cinobufagin-induced apoptosis was confirmed using gain and loss-of function assays. Surface-modified functionalized polycaprolactone scaffolds for bone repair: in vitro and in vivo experiments.

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The proposed FBP reconstruction algorithm was evaluated using Monte Carlo simulated phantom data, including a two-point-source phantom and the Hoffman brain phantom. FoxP3 enhances HIV-1 gene expression by modulating NFkappaB occupancy at the long terminal repeat in human T cells.

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This chapter summarizes the state-of-art in this field and describes methods elementary for preclinical studies of mRNA-based antitumor vaccine protocols. The present study shows that addition of Dip to GTN cannot reverse GTN tolerance. Thus, the results of the present study points towards the essentiality of the central 5-HT transmission at the synapse for the ethanol-induced antidepressant-like effect in the FST wherein the regulatory role of the 5-HT1A receptor or contributory role of the 5-HT2A/2C receptor-mediated mechanism is proposed in the anti-immobility effect of acute ethanol in mouse FST. At the same time, perftoran essentially reduces exudate volume, however this effect is short-time upon single infusion of the preparation.

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The Titrimetric Adjustment of the Hydrogen Ion Concentration of Bacteriologic Culture Media. Our studies show that the complement factor D gene knockout mice are a novel model of spontaneous mesangial immune complex glomerulonephritis. Non-invasive fetal electrocardiography (ECG) can be used for prolonged monitoring of the fetal heart rate (FHR).

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The effect of unsaturated fatty acids on Lactobacillus helveticus and other Gram-positive micro-organisms. Therefore, uroandrologists are challenged with the compelling task of assessing the infertile man considering both his general and his reproductive health, since relevant comorbid conditions may influence not only his life expectancy, but his fertility as well. Recent studies in animal models indicate that the lineage of the tumour-initiating cell may contribute to the biological and genomic phenotype of glioblastoma.

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Scanning and transmission electron microscopy were used to provide observations of the sample surface at different scales. Bioko Island, Equatorial Guinea, has been subject to comprehensive malaria control interventions since 2004. Authors screened all titles and abstracts and read full text article, and two case-control studies were found relevant.

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The aim of this study was to analyze the morphologic changes, conformability, and angulation factors in patients who underwent stainless steel-based stent graft repair of thoracic aortic pathology. Giardia lamblia transcriptome analysis using TSS-Seq and RNA-Seq. As expected, GPx1 expression was negligible in GPx1-deficient mice but was upregulated in wild-type mice in response to light insult.

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Treatment options to terminate persistent cesarean scar pregnancy. The relation of a fat-free diet to the scaly tail condition in rats described by Burr and Burr. This study examined how such labels may influence parents and which labels are most impactful. A multivariate regression analysis was performed to test the factors that could affect the facial nerve outcome in each group. Renal biopsy remains the gold standard investigation for both diagnostic and prognostic purposes in the clinical management of lupus nephritis.

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Prognosis of patients with benign paroxysmal positional vertigo treated with repositioning manoeuvres. To determine if cytokines could also lead to upregulation of JD118 antigen, alpha-interferon (alpha-IFN), gamma-interferon (gamma-IFN), interleukin 2 (IL-2), or IL-4 were added to fresh neoplastic B cells in serum-free media and changes in JD118 antigen expression were evaluated by flow cytometry (FCM). Based on conservation of sequence motifs and organization of these motifs in the domains, LpR resembles most the groups of the LDLRs, very low density lipoprotein (VLDL) receptors, and vitellogenin receptors. Our study identified a new pDC regulatory mechanism by which the same CD28 molecule that promotes stimulation in most cells that express it is co-opted to negatively regulate pDC IFN-I production and limit innate responses.

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Protein alterations associated with temozolomide resistance in subclones of human glioblastoma cell lines. Using this original approach, we demonstrate that the tPA binds the NTD of the GluN1 subunit at a lysine in position 178. Thymidylate synthase (TS) is an important enzyme for DNA synthesis and the target for 5-fluorouracil (5-FU). Towards ultrahigh volumetric capacitance: graphene derived highly dense but porous carbons for supercapacitors. It mentions the basic trends in the pattern of ocular traumatism.

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Furthermore, the autoactivation of a variant enzyme with a single replacement, FheproCL1Pro-12, was very slow but was increased 40-fold in the presence of FheCL2. Plasma-derived products are produced from plasma via fractionation and chromatography techniques, but can also be produced by other methods. Structural Determinants in the Binding of BB2 Receptor Ligands: In Silico, X-Ray and NMR Studies in PD176252 Analogues. Abundances and number of taxa of benthic invertebrates were at least one order of magnitude smaller in impacted areas than in controls. The in vivo efficacy of nonglycosylated recombinant human granulocyte-macrophage colony stimulating factor (rh GM-CSF) expressed in Escherichia coli was studied in cynomolgus monkeys (Macaca fascicularis).

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Several efforts were made to investigate the three-dimensional (3D) image of lesion, only to gain little popularity. The genes mecA, lukS-PV/lukF-PV, and ACME-arcA were detected by PCR. Undernutrition in old age is associated with increased morbidity, mortality and health care costs.

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Yeast THO1 and SUB2 (Saccharomyces cerevisiae) were identified as multicopy suppressors of the expression defects of the hpr1Delta mutant of THO. Second-generation aptamer-conjugated PSMA-targeted delivery system for prostate cancer therapy.

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Aspiration of oocytes from mature and immature preovulatory follicles in the mare. Last, the article concludes that the Pennsylvania Patient Safety Authority exemplifies a major step forward on a long and difficult path toward patient safety. Synaptonemal complexes (SCs) are not formed during meiotic prophase in the fission yeast, Schizosaccharomyces pombe. Here we developed a novel mixed mode chromatography method using the unique property of Sepax Zenix SEC-300MK column to analyze mAb oxidation levels. Development and validation of a real-time PCR assay for the glassy-winged sharpshooter Homalodisca vitripennis (Hemiptera: Cicadellidae).

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The present study extends earlier works on the role of brain-derived neurotrophic factor (BDNF) in regulating the antidepressant-like actions of naringenin in chronic unpredictable mild stress (CUMS). Reliability of the hazelbaker assessment tool for lingual frenulum function. Recently, it has been recognized that both cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) produce important endogenous factors of human tumor progression.

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Our standardized operation, which we call the pelvic floor-lifting, is a combination of well-established colorectal and gynecological operative steps and the application of surgical principles for hernia repair. In the presence of lactate with hydroxymethylferrocene (HMF) as a redox mediator in solution, biosensors obtained by direct adsorption of LOx onto GC electrodes exhibited a clear electrocatalytic activity, and lactate could be determined amperometrically at 300 mV versus SSCE. Differently from traditional conceptual distance measurements, which are based on Web textual documents, FD is based on the visual information.

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A broad search strategy was used, including searching international and local databases, research reports, and extensive personal contacts. Because almost half of the deliveries in developing countries occur at home, under-reporting of stillbirths is a huge problem, and reliable data about rates and causes are difficult to obtain. Training Monitoring for Resistance Exercise: Theory and Applications. The only pharmacological factor with clinical data is teriparatide, but more data are needed to confirm its effect on fracture healing in humans, even if experimental data in animals are robust. In recent years several reports have suggested that T cells may have a role in systemic sclerosis (SSc).

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meliloti strains by ammonium was only observed for rhizobial plasmids, not for a heterologous plasmid such as RP4. The type of movement that allowed for the most accurate results consisted of several flexion-extension/abduction-adduction movements performed on vertical planes of different orientations, followed by a circumduction movement. Their structures as novel antibiotics and cytotoxic agents were elucidated by mass spectrometry and NMR spectroscopic methods.

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In this paper, we tried to summarize the prognostic scoring systems and their performances in assessing severity and prognosis of acute pancreatitis. Rabbits were divided into two groups according to size of the wounds: Group 1--A and B (4 cm2) and Group 2--A and B (25 cm2).

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A technique for long-term collection of uterine contents from mares. Decay of follicle-stimulating hormone-beta messenger RNA in the presence of transcriptional inhibitors and/or inhibin, activin, or follistatin.

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Current problems on the management of HTLV-1 asymptomatic carriers and ATL patients Larger trials with more rigorous controls need to target promising interventions. Often, this condition may be accentuated by medication (digitalis, diuretics, antiarrhythmics), so that they become more sensitive to electrolyte disturbances, reacting sometimes violently with severe and life threatening rhythm troubles.

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According to our results, the extraction method using ammonium acetate proved to be simple and suitable for obtaining DNA of good quality, which can be easily amplified by PCR. The laser beam profile and power characteristics are shown to agree with theory. Courses and reading journals were felt to be better at changing knowledge while all the other modes (vide intra) were felt to be better at changing practice, except computer assisted learning (CAL). For the combination of clotting complications and disseminated intravascular coagulation, there was a significantly higher prevalence in the iNO group.

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Comparative studies in tissue culture suggested that MVV was related to RNA tumor viruses of animals, the oncornaviruses. Left ventricular endocardial irregularity: evaluation using epicardial echocardiography. Firing rates in V1 were suppressed over the first 2 day of MD but then rebounded to baseline over the next 2-3 days despite continued MD.

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These features included UMLS concepts and their semantic groups, semantic predications extracted by SemRep, patient population identified by a pattern-based natural language processing (NLP) algorithm, and cue words extracted by a feature selection technique. The rate of possession of each antigen was compared between the two populations. Older adults practicing the task with fast PT gained less than older adults practicing the task with slow PT, probably reflecting the persistent use of a selective strategy throughout the 100-day practice period in the fast PT group. However, because these procedures resulted in major morbidities and mortalities, alternative modes of treatment were sought.

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Our results support the idea that suprathreshold contrast perception and its adaptational shifts are jointly determined by responses between monocular and binocular units. The blogosphere is full of personalities with masks, or pseudonyms. Environmental sustainability in the national health service in England. We compared the incidence of hepatotoxicity with that in 11 patients treated intravenously during the first week.

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Emergency endoscopic examination was performed, however tissue adhesive utilized to restrain the bleeding was not successful. Collectively, our data show the existence of cooperative actions between Aur-A and Plk1 mitotic kinases in response to taxol, providing a molecular explanation for the action mechanism of taxol. Acute peripheral blood flow response induced by passive leg cycle exercise in people with spinal cord injury.

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A sequence is proposed that couples DNA damage to Bid translocation via activation of c-abl and p73. The different strategies that could be used in this critical situation are reviewed. Mebrophenhydraminum hydrochloricum (Mebrophenhydramine hydrochloride

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Momentum from the water velocity during runoff events created flow through the sampler resulting in velocity dependent sampling. The cell apoptosis induced by TNF-alpha along or in combination with U73122 was detected by flow cytometry with PI staining.

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Testosterone improves the transition of primary oocytes in artificial maturation eels (Anguilla japonica) by altering ovarian PTEN expression. Real-time quantitative reverse transcription PCR was employed to detect the expressions of miR-449a/b and miR-34b, c in SKOV3 and SKOV3-ipl cells. While extensive research has greatly improved our understanding of the molecular mechanisms that constitute the circadian clock, the links between this clock and dependent processes have remained elusive. Serum levels of human hepatocyte growth factor (hHGF) in patients with various liver diseases were determined using an ELISA kit to explore its clinical significance. A follow-up program for mother and child would help its early diagnosis and management.

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Development of a numerical simulator of human swallowing using a particle method (part 1. Assessment reactivity may be a factor in the modest results of brief interventions for substance use in the emergency department (ED). The occurrence of guanine propionate in Claviceps paspali Stevens and Hall. The high prevalence of atrial fibrillation in aging populations leads to an increasing incidence of vitamin K antagonists-associated intracerebral hemorrhages (VKAs-ICH).

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The choice of subcutaneous pedicle propeller flap should be emphasised because of the superior functional results of flap as well as ease to learn it. Typhimurium encodes a LuxR homolog, SdiA, which detects N-acylhomoserine lactones (AHLs) produced by Y. Modeling the Effect of External Carbon Source Addition under Different Electron Acceptor Conditions in Biological Nutrient Removal Activated Sludge Systems. The measurement of HIV risk level in African American women who dwell in the Southeastern United States. Ovarian cancer is responsible for the largest proportion of deaths among patients with gynecologic cancer.

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Manipulation of regulators of gene expression at both transcriptional (i.e., sirtuins) and posttranscriptional (i.e., mRNA binding protein Pub1) levels allows to modulate yeast life span during its biotechnological use. Observation of a nematic quantum Hall liquid on the surface of bismuth.

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Temperature sensitivity increases as the average radius of CdTe quantum dots decreases. The initial aim of the collaboration was to combine knowledge from these two fields in order to move from a classical one-brain neuroscience towards a novel two-body approach.

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Patient perceptions of allergic rhinitis and quality of life: findings from a survey conducted in europe and the United States. The single cell gel electrophoresis (SCGE) assay is a rapid, simple, visual and sensitive technique for measuring DNA breakage in individual mammalian cells. Intervention strategies aimed at combating the spread of HIV and other sexually transmitted infections (STI)s should treat sexual partnerships as social units and fully incorporate the effects of migration in their strategies. Inhibition of choline acetyltransferase and hexobarbitone-metabolizing enzymes by naphthylvinyl pyridine analogues.