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Dapsone (Dapoxetine)
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Dapoxetine

Dapsone is a selective serotonin reuptake inhibitor, for the treatment of premature ejaculation. In a phase II proof-of-concept study conducted by PPD, Dapsone demonstrated a statistically significant increase in ejaculatory latency when compared to placebo. Alza submitted a NDA to the FDA for Dapsone for the treatment of premature ejaculation in December 2004. In October 2005, the company received a FDA Non-Approvable letter from the FDA, at which time they planned to work with regulators to address outstanding questions.

Other names for this medication:
Dapoxetine, Actinex, Aczone, Dapoxetin, Dapoxetina, Dapsone, Dejac, Duraject, Duralast, Poxet, Priligy, Tadapox, Viglast, Westoxetin, Xydar,

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VARIATIONS IN NORMAL AND BRUCELLA-IMMUNE RABBIT SERUM AS DETERMINED BY PAPER-PARTITION CHROMATOGRAPHY. Natural selection at the class II major histocompatibility complex loci of mammals. Comparison of enhanced depth imaging and high-penetration optical coherence tomography for imaging deep optic nerve head and parapapillary structures. cFFR is reproducible and can be achieved with usual volumes of contrast.

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Using interview excerpts, we discuss how through the use of joint interviews researchers can explore the intersubjective and heteroglossic nature of illness experiences. We aimed to assess factors that have an impact on the choice of dialysis modality in children and young adults in France and sought to determine the roles of medical factors and center practices. Downregulation of the PAR expression increases the Bax/Bcl-2 ratio and Bax expression, and thus induces the G2-M phase arrest and apoptosis of PC3 cells. Solution structure by 2D 1H-NMR of a chimeric peptide recognized by galanin and neuropeptide Y receptors. The pathophysiologic mechanisms behind proliferation of fibroblasts and deposition of dense collagen matrix in idiopathic frozen shoulder remain unclear.

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Responsiveness of Western adults to pitch-distributional information in melodic sequences. While the latex-derived allergens are of sizeable molecular weight and behave as regular complete allergens, most of the other compounds are low molecular weight molecules behaving as incomplete allergens or haptens. However, increased grant revenues had a negative association with technical efficiency for health centers that were not fully efficient. We show RCAN1 induction in atherosclerotic human and mouse tissues. Suggestions for prevention include education, control to avoid critical situations, and a judicial system to assess malpractices.

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Distinguishing between (non)persistence and implementation is important in clinical practice, and may require different interventions in routine consultations. We obtain several typical waveforms such as square waveform, triangular waveform, flat-top waveform, sawtooth waveform, Gaussian waveform and so on. In this study, the proposed iSSO-KHM is based on an improved simplified swarm optimization (iSSO) and integrates a variable neighborhood search (VNS) for KHM clustering. Application of kinetic-based computer modelling to evaluate the efficacy of HI 6 in percutaneous VX poisoning. Combined exposure to nicotine and ethanol throughout full gestation results in enhanced acquisition of nicotine self-administration in young adult rat offspring.

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In the results of paraquat group compared to control group, there was statistical pharmacokinetic difference for bupropion, tolbutamide, metoprolol, midazolam and omeprazole. The effect of serving as a psychotherapist on students with different specialty preferences.

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The key is that isotope spectra can be measured without interference from co-eluting fatty acids or other molecules. In embryonic brain extracts, Diaph3 co-immunoprecipitates with BubR1, a key regulator of the spindle assembly checkpoint (SAC). Conflicting data exist regarding the impact of reversible pulmonary hypertension (PHTN) on post-transplant (Tx) outcomes. Thirty-four per cent of the direct care staff had less than a high-school education. The current data suggest that MPc has oxidative-stress-inducing potential in fish, and that gills and white muscle are the most sensitive organs of B.

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Evidence on aspects concerning usual primary care that actually have an impact on HRQoL remains scarce. Epilepsy is the most common neurological disorder affecting approximately 50 million people worldwide.

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In this field, efforts are now being made to move from intraoperative naming-assisted surgical resection towards the use of other language and cognitive tasks. This thorough exploration using site-directed mutants provides key mechanistic insights to guide the rational manipulation of the proteins that are key players in extracellular electron transfer processes, towards the improvement of microbial electrochemical applications using dissimilatory metal-reducing bacteria. Therefore, our results indicate that BMP4 stimulation blocks the differentiation of endocrine progenitor cells and instead promotes their expansion thereby revealing a novel paradigm of signaling explaining the balance between expansion and differentiation of pancreatic duct epithelial progenitors. Thus, without activity of the transcription factor required for terminal differentiation, even relatively mature and committed cells proliferate continuously with the differentiation capacity to other lineages.

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Penetration of anti-infective agents into pulmonary epithelial lining fluid: focus on antifungal, antitubercular and miscellaneous anti-infective agents. Especially during the heavy polluted days, the effects of elevated concentration of PM2.5 on hospital emergency room visits were much larger. Three-dimensional CT was performed to confirm the diagnosis of atlanto-occipital dislocation and precisely evaluate the magnitude of displacement. The data demonstrated that pachytene spermatocyte-specific genes elicited explicit down-regulation in parallel with the progression of spermatocyte death, while other gene sets did not show characteristic expression changes.

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Fusion of diphtheria toxin and urotensin II produces a neurotoxin selective for cholinergic neurons in the rat mesopontine tegmentum. In these strains, cprA5 transcripts were detected only in the presence of chlorophenols. Naturalistic study on the effectiveness of psycho-oncological interventions in cancer patients and their partners. To provide an update on the histopathologic pattern of bladder cancers in our community and to explore its implications for future health system policies.

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Four overlapping fragments of the gene encoding SA I/II were amplified by polymerase chain reaction, cloned, and expressed in Escherichia coli. By contrast significant correlation between several SWAP parameters and OCT parameters were detected. Weight loss surgery is an increasingly common treatment option for obese adolescents, but data are limited regarding the metabolic effects of surgical weight loss procedures. acidilactici ATCC 12697 were then used to examine lactose-positive pediococci for properties related to milk fermentation. Moreover, these PK activities were inhibited by using Flavopiridol, a known CDKs inhibitor.

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Cost-Effectiveness Analysis of Heat and Moisture Exchangers in Mechanically Ventilated Critically Ill Patients. We propose a new signal assignment approach for metabolite mixtures by assembling H-H, H-C, C-C, and Q-C fragmental information obtained by multidimensional NMR, followed by the application of graph and network theory. Patients were divided into 2 groups according to the tumor defect pattern during the Kupffer phase.

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Characterization of the recognition specificity of autoreactive, polyspecific monoclonal antibodies obtained from spleen cells of parasite-infected BALB/c mice. Direct standardisation using the world population was made to adjust for the changing age structure. Interaction between HIV protease inhibitors (PIs) and hepatic transporters in sandwich cultured human hepatocytes: implication for PI-based DDIs.

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Total pancreatectomy is infrequently performed for pancreatic cancer. Focal pathomorphological disorders during aging of the nerve trunks Results were analyzed using statistical package for social sciences (SPSS) version 11.

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Numerous studies on the OPD indicate areas of possible improvement, for example for clinical purposes the OPD should be more practically formulated. As a potential natural pesticide, cinnamaldehyde was successfully produced in E. Nitrogen removal by Chelatococcus daeguensis TAD1 and its denitrification gene identification. Some of the detection modalities that are discussed in this review include fluorescence, colorimetric, chemiluminescence, and electrochemical methods.

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Re: Urinary TMPRSS2:ERG and PCA3 in an active surveillance cohort: results from a baseline analysis in the Canary Prostate Active Surveillance Study. The high quality and high frequency measurements provided by a titrimetric set-up measuring the total ammonium (TAN) and total nitrite (TNO2) concentrations facilitate this control considerably.

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These results indicate that the human strains correspond to those designated biotype I whereas ATCC 9935 belongs to biotype II and ATCC 9934 to biotype III. This paper addresses the different natural/anthropogenic sources which generate these pollutants, their toxicity profile, different physico-chemical treatment methods and especially focuses on biological methods of treatment and combination of these for the efficient removal to achieve a treated effluent quality fit for disposal without causing any damage to the environment. Rifampin is a widely used antimicrobial that has major interactions with several medications including warfarin due to its strong P-glycoprotein and liver enzyme inducer activity especially on CYP2C9, CYP3A4, CYP1A2 and CYP2C19.

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Comparison of genetic properties of influenza viruses before and after repeated passages in monkey kidney cell culture. This study demonstrates that prostacyclin plays an important, but previously unrecognized, role in central nervous system function and behavior. Pseudomyxoma peritonei is a rare disease characterized by diffuse intraperitoneal mucinous tumor and massive mucinous ascites. Following subcutaneous injection of SPIOs, iron deposition is found predominantly in sinuses and the subcapsular space and is not found in areas containing metastases.

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The primary defect in the incisor ligament leads to halted tooth eruption. Is sex an independent prognostic factor in cutaneous head and neck melanoma? This is important for the clinical translation of Raman spectroscopy because of the resulting decrease in total imaging time for each measurement and because the surgeon can now acquire spectroscopic data with no disruption of the surgical workflow. Ischemic stroke patient characteristics, in-hospital care, and early outcomes (adjusted for case mix) were compared for participating centers. To analyze the tissue repair behavior after corrective surgical incision in neonates submitted to low-level laser therapy, in an attempt to diminish the incidence of postoperative dehiscence following the surgery for myelomeningocele performed immediately after birth.

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Reproductive factors, gynecologic operations and exogenous hormones. CTCs were defined as nucleated cells positive for cytokeratins and negative for CD45. Ultrasensitive HIV RNA, peripheral blood mononuclear cell (PBMC)-associated HIV DNA, HIV-specific T-cell responses (ie, production of cytokines and capacity to suppress HIV infection), reactivation of the CD4 cell reservoir (measured by p24 ELISA and HIV RNA in supernatants upon phytohaemagglutinin activation of purified CD4 cells), and plasma concentrations of antiretroviral drugs were assessed after 10 years of documented control off therapy.

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Preconception biomarkers of allostatic load and racial disparities in adverse birth outcomes: the Bogalusa Heart Study. Active surveillance for prostate cancer: an underutilized opportunity for reducing harm.

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Deleting EAP1 reduced cell adhesion to polystyrene and epithelial cells in a gene dosage-dependent manner. Streptococcus pneumoniae infection regulates expression of neurotrophic factors in the olfactory bulb and cultured olfactory ensheathing cells. The methodological challenges can be categorized in six developmental research stages, comprising the conceptualization of experiential expertise, methods to harvest experiential expertise, the validation of experiential expertise, evaluation of the effectiveness, how to translate experiential expertise into acceptable guidelines, and how to implement these. The role of S stercoralis enzyme-linked immunosorbent assay (ELISA) in this context was examined.

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The attenuation was now even briefer, the recovery more rapid, and the facilitation more robust. Five patients received subretinal TPA with vitrectomy and 15 patients received intravitreal injection of TPA and gas to remove or displace the submacular hemorrhage. These results show that the juvenile rat brains mostly respond to ischemia by a COX-2-dependent prostaglandins production and suggest that the transcriptional responses observed under 7-NI facilitate and reorient COX-2-dependent prostaglandins production.

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In contrast the hospital clinical laboratory is most effective at performing rapid turn-around, routine, high volume testing. The discovered phenomenon could find its applications in methods for microparticle manipulation and separation. The distribution of elements was related to their symbiotic function.

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The cornea was replaced by thick fibrous membrane, the iris and the lens were not revealed. Role of ACTH not only in lung maturation, but also in onset of labor was proved in the mechanism of influence on immunologic tolerance. Fast-track surgery is a novel approach which uses a multimodal package of changes to traditional surgical care to reduce the stress response evoked by surgery allowing for enhanced recovery times. This study also highlights the importance of ligand solubility for successful Xray crystallographic campaigns in lead compound design.

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Immune status was determined by phenotypic analysis of lymphocyte populations and the activation of mononuclear cells. This fact points to the ethylcellulose shell efficiently coating carbonyl iron, and leading to composite particles which, from the electrokinetic point of view, are almost indistinguishable from latex. Posterior soft tissue repair after posterior THA reportedly decreases the risk of dislocation.

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Unfortunately, the modern lifestyle seems to contribute to increasing alterations in redox balance and circadian rhythms, thereby posing a critical problem for normal functioning of the living system. This review covers the amyotrophic lateral sclerosis (ALS)/parkinsonism dementia complex (PDC) of Guam. High VEGF-A level at baseline predicts poor treatment effect of bevacizumab-based chemotherapy in metastatic colorectal cancer: a meta-analysis. Signal transduction and regulation of gene expression induced by PDGF-BB and -DD were compared in primary human mesangial cells (HMCs), which expressed PDGF alpha- and beta-receptor subunits.

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We retrospectively analyzed the survival of 207 gastric cancer patients (stage IB: 19, II: 65, IIIA: 58, IIIB: 28, IV: 37) who underwent 5-fluorouracil (5-FU), mitomycin-C (MMC), and polysaccharide-K (PSK) chemoimmunotherapy (CITX) after curative resection (FM group). Recurrent neural networks (RNNs) are useful tools for learning nonlinear relationships between time-varying inputs and outputs with complex temporal dependencies. Gender and age group differences in domestic MVPA activity and the ratio of domestic to total MVPA were explored using non-parametric Kruskal-Wallis tests.

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Strain-related variation in the persistence of influenza A virus in three types of water: distilled water, filtered surface water, and intact surface water. Increased awareness of its histological features should help prevent such misdiagnoses.

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In this paper the coherence requirement for different holographic setups (Fresnel hologram, Fourier hologram, and image-plane hologram) is compared. The area of superficial FAZ and the parafoveal VD are correlated with best-corrected visual acuity in eyes with RVO. A minority of chronic myeloid leukaemia (CML) patients express variant transcripts of which the e19a2 BCR-ABL1 fusion is the most common.

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Our study shows a sub-structured parasite population with clonal propagation, with most of its components recently affected by bottleneck events. Urinary sediment components are mainly unstable, especially in their original forms. Neuromuscular development in Drosophila: insights from single neurons and single genes.

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Differential gene expression reveals mitochondrial dysfunction in an imprinting center deletion mouse model of Prader-Willi syndrome. This was a prospective, observational study of 150 elderly patients receiving warfarin anticoagulation who were acutely hospitalised in a tertiary hospital. Corrigendum: Fish oil supplements in New Zealand are highly oxidised and do not meet label content of n-3 PUFA. Thus, to achieve the required precision and granularity of chemical class definitions, sets of SMARTS class definitions are connected by OR and NOT logical operators. The activity of PON and ARE were significantly decreased, and oxidative stress was increased in patients with SH.

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Involvement of the maternal and fetal immune systems in the events of pregnancy was generally overlooked by reproductive biologists until the mid-twentieth century when many landmark explorations were reported. Kinetic modeling of cellulose hydrolysis with first order inactivation of adsorbed cellulase. To the best of our knowledge this is the first case report in literature about quadruple major total joint arthroplasty implanted during the same anesthesia in the same patient.

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In response to guidance issued by the Food and Drug Administration, thousands of patients have been enrolled in large randomized trials evaluating the cardiovascular effects of the three newest diabetes drug classes: glucagon-like peptide-1 (GLP-1) receptor agonists, sodium glucose cotransporter 2 (SGLT-2) inhibitors, and dipeptidyl peptidase-4 (DPP-4) inhibitors. In strain typing, PFGE was the highly discriminatory method comparing to the MLST system. A discussion regarding etiology and prognosis is presented after the EEG pattern is described in detail.

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A dose-escalation phase to determine the MTD of R-INO was followed by an expanded cohort to further evaluate the efficacy and safety at the MTD. The inflammation of aging hypothesis purports that aging is the accumulation of damage, which results, in part, from chronic activation of inflammation process. The highest shear bond strengths were obtained in sandblast and acid etch treatment for zirconia oxide and lithium disilicate groups, and in acid etch treatment for metal alloy group. Bicarbonate induces sensitization of cyclic AMP accumulation by intact 1321N1 human astrocytoma cells.

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Using fluorogenic probes that were specifically activated by glucuronidase we could show 1) preferential activation in tumors, 2) renal excretion of the activated fluorescent compounds and 3) reproducible detection of GusA in the serum of amantadine drug bank oncolytic vaccinia virus treated, tumor bearing mice in several tumor models. These data indicate that inhibiting phenylpropanoid biosynthesis with AIP is an effective approach to reduce tissue browning in A. Our primary objective was to evaluate the degree to which estimates of outdoor environmental LAN predict 6-sulftoxymelatonin (aMT6s), the primary urinary metabolite of melatonin. Efficient ex vivo gene transfer into non-human primate hepatocytes using HIV-1 derived lentiviral vectors. To determine the type and rate by age, gender, and vaccine received for reported hypersensitivity reactions following monovalent 2009 pandemic influenza A (H1N1) vaccines.

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Enhanced OCT4 transcriptional activity substitutes for exogenous SOX2 in cellular reprogramming. coronata in Spain for the first time, replacing all previous records of O. We report here a lansoprazole tablet formulation development simple, standardizable protocol for the large-scale comparative quantitative proteome characterization of different Arabidopsis organs based on normalized spectral counting and suggest a statistical framework for data interpretation. The combination was useful in detecting dementia but it does not replace the need for detailed neuropsychological tests. Cytogenetic monitoring by use of the micronucleus assay among hospital workers exposed to low doses of ionizing radiation.

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This finding supports the application of anthropometry for determining trunk fat in clinical and epidemiological settings. Toxicity of clinically relevant drugs (cisplatin, gentamicin, glyoxylate, cyclosporine A, p-aminophenol) was significantly decreased in cells preconditioned by effects secondaires mopral medicaments homeopathiques tunicamycin or DTTox.

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Although GATA3 labeling is highest in estrogen receptor-positive carcinomas, it also labels estrogen receptor-negative carcinomas and thus has particular diagnostic utility in the setting of triple-negative breast carcinomas, which are typically negative for other mammary-specific markers. Binding of threonine and of pyridine nucleotides: stoichiometry and optical effects. Response of mouse sarcoma-180 to bleomycin in combination with radiation and hyperthermia. The C-nitroso compound 3-nitrosobenzamide, which has been shown to remove zinc from lansacid tablet table the retroviral-type zinc finger of p7NC nucleocapsid proteins, inhibits acute infection of human immunodeficiency virus type 1 in cultured human lymphocytes.

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The increase was zopim olark alternative medicine evident 5 h after challenge and persisted at 24 h. This article describes 2 patients whose dental abutments were prepared to receive ceramic restorations using vertical preparation without a finish line. Our findings suggest that costs attributable to HCC are significant in Canada and expected to increase. The Calmodulin-like calcium binding protein EhCaBP3 of Entamoeba histolytica regulates phagocytosis and is involved in actin dynamics.

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The marked increase in the total plasma methadone concentration observed in gel unghie e micosin our patient, and the enhanced pharmacodynamic effect, appear primarily due to a reduced volume of distribution. Similarly, Doppler sonography revealed an echo-poor wall change with outward bulging and slight narrowing of the affected vessel lumen.

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Analysis of the trajectories indicates that hydrophobic interactions are primarily responsible for the formation and stability of the inclusion complexes. We propose novel miRNA-centric functional enrichment measures in a conceptual framework that connects the spaces of miRNAs, genes, and GO terms in a unified way. Acute nephritis was induced in mice by single injection of nephrotoxic serum amtas 5 tablets pc (NTS), followed by PGE2 administration with severity of nephritis evaluated over time.

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A net-like structure with pores is observed during cell fusion induced by the receptor FGFRL1. Growth, growth hormone testing and response to fluvin 25 mg que es la growth hormone treatment in Gitelman syndrome. Nitric oxide and regulation of heart rate in patients with postural tachycardia syndrome and healthy subjects. This report describes a case of primary Streptococcus pneumoniae bacteremia with prosthetic joint infection caused by serotype 6C with recurrent infection in a patient with a history of congenital asplenia and underlying autoimmune disease. During surgery, the cyst was completely removed, and his symptoms/signs resolved.

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We report the development of isotopic-labeled (13)C diffusion-ordered NMR spectroscopy prinivil nombre generico de relafen (DOSY) NMR with diffusion coefficient-formula weight (D-FW) analysis and its application in characterizing the aggregation state of methyllithium aggregates and complexes with several widely used diamines. To demonstrate the functionality of the chip design, a lipid membrane permeability assay is performed. Cooper test showed that no rotational instability at 90 degrees except 1 cases at 30 degrees with less than 5 degrees. From a biosynthetic viewpoint, this compound possesses structurally interesting features such as an unusual furanosyl sugar moiety, which are absent in the well-studied staurosporine and rebeccamycin. Both the 50- and 60-kDa glycoproteins remained immunoreactive after treatment with the glycosidases.