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Pennsaid comes as a tablet, and liquid-filled capsule, a hard gelatin capsule, an extended-release (long-acting) tablet, a delayed-release (releases medication in the intestine) tablet, and as packets of powder for solution (to be mixed with water) and taken by mouth. Pennsaid liquid-filled capsules are usually taken 4 times a day and Pennsaid hard gelatin capsules are usually taken 3 times a day on an empty stomach. Pennsaid extended-release tablets are usually taken once a day, and in rare cases are taken twice a day, if needed to control pain. Pennsaid tablets and Pennsaid delayed-release tablets are usually taken 2, 3, or 4 times a day. Pennsaid solution is taken without food as a one dose treatment to relieve the pain of migraine headaches. If you were told to take Pennsaid on a regular basis, take it at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Pennsaid exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Different Pennsaid products release the medication differently in your body and cannot be used interchangeably. Only take the Pennsaid product prescribed by your doctor and do not switch to a different Pennsaid product unless your doctor says that you should.

Your doctor may adjust the dose of your medication during your treatment depending on your response to the medication. Talk to your doctor about how you are feeling during your treatment with Pennsaid.

If you are taking the powder for solution, you will need to mix it with water before you take it. To mix the medication, first remove one packet from a row of three attached packets. Place 2 to 4 tablespoons (1 to 2 ounces; 30 to 60 mL) of water in a cup. Add the contents of the packet and mix well. Drink the entire mixture right away. Throw away the empty packet in a trash can that is out of the reach of children and pets.

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